Revisiting the Fundamentals of Untargeted Data Analysis with Comprehensive Two-Dimensional Gas Chromatography (GC×GC): With Great Peak Capacity, There Must Also Come Great Responsibility

This article provides a general overview of untargeted analysis using comprehensive two-dimensional gas chromatography (GC×GC), while revisiting some fundamental aspects method development. The original definition chemometrics is also revised according to the latest developments field. We discuss how GC×GC has become an important backbone for new strategies in separation science, especially multivariate data analysis. concept pixel revisited, as pixel-based processing method, namely Fisher ratio proposed by Synovec and coworkers, been successfully implemented software GC×GC.